Title: Idiopathic hypereosinophilic syndrome with presenting bilateral pleural effusion and pericardial effusion causing cardiac tamponade together

Abstract:Idiopathic hypereosinophilic syndrome (IHES) is a leukoproliferative disorder with hypereosinophilia. The most common presentation is a cardiac manifestation, such as myocarditis. The pericardial effusion is a rare presentation of IHES, and it is even rarer for pericardial effusion and both pleural effusion to be expressed together.\nA 24-year-old male was admitted to our hospital with dyspnea, cough, and chest pain. Imaging studies showed bilateral pleural effusion and pericardial effusion. Effusion fluid analysis revealed elevated eosinophil count. His blood test also showed eosinophilia, and he didn\'t have any other diseases which cause eosinophilia. The histologic section of the pleura and pericardium showed eosinophilic infiltration in mesothelium. We diagnosed him with IHES with bilateral pleural and pericardial effusion together without cardiac involvement, which was a rare case among the IHES. We treated him with a high dose of steroid, and one month later, his eosinophilic count and chest X-ray returned to normal.

Title: Determination of minimal inhibitory concentration (MIC) of cadmium for Brevibacillus agri C15 and B. agri C15 CdR

Abstract:Precise determination of resistance by MIC assay is important in handling bacteria. Here we describe a protocol for identifying the MIC of B. agri C15 and B. agri C15 CdR with the hope of assisting researchers to correctly confirm the resistance of isolates .Its minimum inhibitory concentration (MIC) to Cd was 16 ± 0.7 mM and 21± 0.4 mM Cd, respectively. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) showed no morphological effects of Cd on either of the strains. The projected assay to determine MIC of cadmium can be applied to the study of new agents with B. agri C15 and B. agri C15 CdR and in laboratory routine for other bacteria

Title: Biosorption of lead ions from aqueous solutions by magnetic biocomposite using experimental design

Abstract:In this study, describes magnetic biocomposite as a biosorbent that use natural renewable resources and reduce adverse effects on the environment. The Pisum sativum peels powder and magnetite was encapsulated into alginate beads in aqueous calcium chloride solution to prepare a biocomposite material. Magnetic biosorption procedure of lead was optimized by Placket Burman Factorial Design. Biocomposite amount, pH, temperature and extraction time were evaluated as optimization parameters. In this work, biosorption yield of lead ions using magnetic biocomposite was calculated as 90±4% percent by Flame Atomic Absorption Spectrometry. Different sorption and thermodynamic parameters have been tested from sorption results by batch technique. The best-fitting isotherm is Freundlich model and theoretical capacity of biosorbent for lead ions was calculated as 74.05 mg/g. The report of biocomposite on the biosorption studies was presented.

Title: Is the His Bundle pacing a last and safe therapy? A 12 months follow-up

Abstract:The benefits of permanent His Bundle Pacing(p-HBP) resides in a physiological ventricular contraction. The development of specific tools that have made easier and faster the implant of the pacing lead in His opens the perspective of a more widespread use of this technique: our aim was to ascertain its long term reliability. Methods: Prospective cohort study including patients who undergone p-HBP with 12 months follow.up. We analyzed: success rate of the implantation, thresholds at follow-up, and complications related to pacemaker implantation at the baseline and after 12 months, including the mortality rates. Results: 72 patients(median age, 73(69-82)years) with a permanent pacing indication, in which p-HBP implantation was chosen as the first option. In 21.1% p-HBP was indicated with the purpose of cardiac resynchronization therapy, according to the heart failure guidelines. Implant success rate was 81.9%(n=59), with a median time of fluoroscopy of 6.5(3.4-13.5) minutes. The median acute His threshold was 1.5(1-2) Volts, at 24 hours 1.25(0.75-1.75) Volts and after 12 months 1.75(1-2.25) Volts. In the follow-up we registered a loss of capture in 5 cases(8.4%), with acceptable thresholds in 54 cases(91.6%). The total mortality rate in the follow-up was 4.2%(3 patients), for causes no related with the pacemaker implantation. Conclusions: p-HBP is a feasible and safe technique in a high percentage of patients, with reasonable fluoroscopy times, acceptable pacing thresholds acutely and at 1 year follow-up. Our results, even if obtained in a small sample, seems to be promising for the spread of this technique

Title: Evolving Ladder of DNA Bar Coding and Sound Prediction

Abstract:Biology has been open to new ideas from varied sources, even non-biological one. This open source behavior has revolutionized research & development in biology. Concept of concurrent usage of two otherwise independent and unrelated concepts is not alien to biology. Therefore, the proposed use of Sound Prediction, applied in biotechnology litigation in conjuncture with DNA bar coding should not be an issue. \nConvergence of these two concepts shall provide predictive ability moving beyond traditional sphere; providing beyond simulation, prediction of actual outcome of the research reducing the present-day risk. Also widening research horizon allowing faster indexing and filling in the blanks in existing genetic spectrum of species, studying and researching phylogenetic linkages, evolutionary analysis to construction of Tree of Life; data discovery, analytics and tracing links within DNA spectrum. It would allow researchers build and test DNA based models, better understood models of DNA spectrum & species identification.

Title: The moose: acoustic direction finding in the service of mating. An example of form follows function.

Abstract:The majestic antlers of the male moose grow anew each year with timing that follows the annual rut cycles of female moose. The antlers are used to facilitate the encounter by allowing the male to find and follow the mating call of the female. We show how both the palmated and un- palmated antlers of the moose and its relatives are effective spherical acoustic reflectors. We follow the annual cycle of male moose reproductive behavior demonstrating how the antler growth cycle is integrated into the reproductive cycle. This paper will show how the need to locate the female causes the sphericality of antlers. This is an evolutionary example of form following function.

Title: Bioactive potential of proline in modulation of antioxidant metabolism and enhancement of stevioside production in callus cultures of Stevia rebaudiana

Abstract:Stevia rebaudiana herb is a major source of high potency sweetener with no calorific value. Present study reports the response of the in vitro cultures of the plant to proline elicitation. Growth parameters and enzymatic antioxidant activities of proline treated cell cultures was determined. Among all the concentrations of proline studied, lower concentrations were found to be more favorable for cell growth and multiplication. This in turn leads to increased production of stevioside. The percentage increase in stevioside content was calculated by quantitative HPLC analysis. Quantification of Stevioside content through HPLC analysis showed that proline treated callus cultures yield higher stevioside content as compared to the non treated ones. Elicitation with proline in callus cultures induced alterations in growth as well as biochemical parameters. In comparison to control, Proline induced oxidative responses were evaluated by a 1.8 folds increase in MDA content. After 21 days of elicitation, catalase activity arose twice over control and ascorbate peroxidase showed a maximum of 40% increase in cultures elicited with proline. Overall, the outcomes of this study can be utilized for the industrial production of stevioside from Stevia rebaudiana through cell cultures.

Title: Electrophysiological profiling and pathological epileptogenic process in the mesial temporal lobe

Abstract:ObjectivePathophysiological mechanisms underlying generation of hippocampal spike is unknown. We analyzed interictal epileptiform activities intraoperatively recorded from the hippocampus and other temporal regions of patients with temporal lobe epilepsy (TLE).MethodsEleven TLE patients with (N=6) or without (N=5) hippocampal sclerosis were included in this study. All of the patients underwent CT, MR Imaging and video-EEG monitoring before the operation for localizing seizure onset and diagnosed as having unilateral mesial temporal lobe focus. After opening the anterior horn of lateral ventricle, recording was made under sevoflurane anesthesia using intrahippocampal multiple electrodes, hippocampal surface electrodes and temporo basal subdural electrodes.Results(1) Frequency of intrahippocampal spike was always higher than spikes from other areas. (2) Intrahippocampal recording demonstrated that there was phase reversal in sclerotic hippocampi but there was not in nonsclerotic hippocampi.(3) Even one transection perpendicular to the long axis desynchronized hippocampal spike.ConclusionWe speculate that the phase reversal occurred at the hippocampal sulcus and the subiculum was the spike generator in sclerotic hippocampus. Mechanisms underlying spike generation is likely to be different between sclerotic hippocampi and nonsclerotic hippocampi. Longitudinal synchronization may be essential for generation of hippocampal spikes. Our data show that hippocampal spikes almost always occur synchronously in different hippocampal regions; Emerson et al (1) have reported that propagation commonly happens from anterior to posterior regions.

Title: COVID-19 4months; Systemic review of WHO reports,cases and deaths in relation to temperature and humidity

Abstract:Background COVID-19 is a respiratory tract disease, caused by new corona virus, was first\nrecognized in Wuhan, China, December 2019. WHO declared it as pandemic on 30 January 2020\nObjectives:To assess relationship between Temperature and humidity and the spread of COVID-\n19 in the top affected regions Methods:We approached a systemic review on 25th of March 2020\nof WHO reports which were 64 by 24th of March regarding number of cases and\ndeaths.Temperature and humidity from December 2019 to June 2020 of the most affected\nregions regarding top 10 affected countries were reviewed using Google weather information\nand AccuWeather.com to asses any relation between them and COVID-19 spread Results: Total\nnumber of cases till 24th of March WHO report was 372755 ,84.84% occur in Top 10 countries;\nChina(81747) ,Italy (63927),United States of America (42164), Spain (33089) ,Germany (29212)\n,Iran(23049),France(19615),South Korea(9037),Switzerland( 8015),United Kingdom (6654).The\nstart of the pandemic and the peak in number of cases in affected regions were all within a\nfavored temperature (40 –55 Fahrenheit ‘F’) and humidity (40-55%) and with increasing weather\ntemperature & humidity the number of cases dropped Conclusion:COVID-19 has favorable\ntemperature and humidity.Pandemic peak reached its end in Wuhan(temperature 68 F-humidity\n88%),resolving in Seoul(temperature 66.2 F-humidity 53%), expected to resolve in Italy ,USA ,\nand Spain in half of April 2020 to its end , and in Germany ,France ,UK and Switzerland in May\nto June 2020.Increasing temperature above 55 F in areas where you can control it , may have\nbeneficial role in controlling COVID-19.

Title: Traditional medicinal systems and homegarden systems: a case study in Cibunar Village, West Java, Indonesia

Abstract:Traditionally, the rural people in the Sundanese region (Tatar Sunda) have been very concerned on the health of their families, including by applying a traditional medical system, including using medicinal plants and herbs. The medicinal plants have been traditionally harvested from various village ecosystems, including homegarden, mixied-garden, and village forest. The utilization of various medical plants is based on Traditional Ecological Knowledge (TEK) and embedded with culture. This research was aimed to access the local perceptions of diseases, causes of diseases, treatment of diseases, and the homegarden system as source of medicinal plants, foods, and ecosystem services. The study was carried out in Cibunar Village of Sumedang District, West Java. Method used in this study was mixed-method of qualitative and quantitative with ethnomedicine and ethnobotanical approach. The result of study showed that that in Sundanese community has vernacular names of disease, including ‘gering’, ‘teu damang’ damang’, ‘teu raraos’, ‘loba nu karasa’, ‘nyareri’, ‘boga panayawat’or sakit in Indonesian. According to the village people the influence of illness can cause poor sleep, and bad eating. Factors that because disease are perceived by the population as a result of weather, food poisoning, work fatigue and accidents, including injury. Treatment of diseases according to the village people is usually undertaken by self-treatment, buy medicine from small shops (warung), go to a community health center (Puskesmas), and go to healer (dukun). The traditional agroforestry systems of homegarden have played an important role as sources of medicinal plants, providing foods, and environmental services, including maintaining soil fertility, soil erosion protection, and adaptation and mitigation of climate change.