Ketamine is a one of prior injectable anesthetics that it\'s usefulness to induce anesthesia or deep CNS suppression in oral administration has not been approved absolutely. Besides Chelidonium majus L. (family Papaveraceae), or greater Celandine, is an important plant in western phytotherapy and in traditional Chinese medicine and exhibit a broad spectrum of biological activities (anti-inflammatory, antimicrobial, choleretic, immunomodulatory, antitumoral, hepatoprotective, diuretic, antitussive, lowering blood pressure, antibilious, cathartic, wormroot in internal uses. Epispastics and flesh wound amneliorator in external uses, anti-osteoporotic activity and radioprotection and eye-regenerative effect). Likewise the herb\'s other important medical properties are: calmative, narcotic, analgesic & anti spasm. As it seems that co administration of celandine and ketamine cause more effective & deep CNS depression effects and also alleviate some of ketamine adverse effects such as spasm, hypertension and eventual convulsions. Ten male cats received different orally doses of Ketamine, celandine & diazepam. Each animal was observed continuously for CNS depression as standard grades on the behavioral scale. Quantal data were obtained by determining the percentage of animals which lost the reflexes (graded as 5 scores) for each dose. Peak scores for each dose and the percentage of animals that reached each peak score is given. Different doses of Ketamine, celandine and diazepam showed dose dependent effect in CNS depression. But, ketamine only exhibited the vigorous effect (score 5). Celandine administration in any Doses could induce only Immobility in animals so as has stronger effect in compare with diazepam. Also celandine reduced pain sensation dose dependently but all of cats reacted to pain in diazepam administration. Also all of animals showed no reaction to pain only in higher dose of ketamine. Results showed that Celandine has better synergism with ketamine to induce vigor CNS suppression in compare with diazepam.